Voltage-gated sodium channels are transmembrane proteins that underlie the rapid depolarisation phase of neuronal action potentials. Aberrant function or expression of specific channel ...

The addictive properties of opioids and the lives shattered by their misuse and overprescription are heavily chronicled chapters of the early 21st century. For over 2 decades, scientists in academia ...

Epileptic encephalopathies are severe early-onset disorders resulting from mutations in the genes encoding voltage-gated sodium channels. These channels regulate the initiation and propagation of ...

Approximately 2% of patients with irritable bowel syndrome (IBS) have a mutation of the SCN5A gene that disrupts sodium channel function, according to a genotype analysis published online March 10 in ...

Hyperactive channels were generally associated with seizure onset in the first week of life. More impaired channel function was more common when the age of seizure onset was older. In fact, almost all ...